

Proton', the main antagonist of Duke Nukem. half a metal face and also a mad scientist) to 'Dr. Manhattan Project is much like the original Duke Nukem due to its many similarities, such as 'Mech Morphix' looking and acting very similar (eg. Manhattan Project is not a direct sequel to any earlier Duke game however, each earlier game in the series featured a completely different story and a new enemy force for Duke to mess up as well, with only the second and third games directly connected chronologically.

Levels in the game contain recognizable parts of New York City. Duke also faces a few enemies who are not mutants, such as Fem-Mechs, lethal whip-wielding gynoids. These enemies include mutated alligators, giant cockroaches, and even the Pig cops from Duke Nukem 3D.

(Gluon Liquid Omega-Phased Plasma) to mutate creatures into deadly monsters in order to take over Manhattan island, New York City. "Manhattan Project features the humorously chauvinistic action hero Duke Nukem, this time fighting Mech Morphix, a mad scientist who is using a radioactive slime dubbed G.L.O.P.P.
