Thus, the altered immunological function of mLNs depends on the intake of dietary lipids. We detected an impaired oral tolerance induction during DIO, but changes were reversible after switching the feed to standard chow. After 10 weeks of feeding oral tolerance induction started, ending up in measuring the delayed-type hypersensitivity reaction, the cell subset composition and cytokine expression. Therefore, mice were fed a high-fat or a low-fat diet for 14 weeks. In this study, the effects of diet-induced obesity (DIO) on mLN induced oral tolerance induction were examined in C57BL/6NCrl mice. In these secondary lymphoid organs, immune responses towards pathogens are generated, or tolerance against harmless antigens is induced.
When dietary lipids are transported via the lymphatics, they pass the mesenteric lymph nodes (mLNs). Obesity increases the risk of several diseases, such as type 2 diabetes mellitus and cardiovascular disease.
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